Pharmacological inhibition of chromatin remodeling enzymes reduces cardiac fibrosis, but the underlying transcriptional regulatory mechanisms remain poorly understood. Using single-cell genomics to profile alterations in the transcriptional and chromatin landscape during stress-induced cardiac remodeling, Alexanian et al. discovered a critical role for Mesenchyme Homeobox 1 in the regulation of myofibroblast activation and cardiac fibrosis.

Life’s Essential 8 are the key measures for improving and maintaining cardiovascular health, as defined by the American Heart Association. Better cardiovascular health helps lower the risk for heart disease, stroke and other major health problems.

Aug 22, 2022 | DAIC Articles

Hackensack Meridian Health, Hackensack University Medical Center cardiac surgeon Yuriy Dudiy, M.D. became the second in the world to successfully implant the Impella Bridge-to-Recovery (BTR) heart pump for the technology’s U.S. Food and Drug Administration (FDA) early feasibility study (EFS) investigational device exemption (IDE). Hackensack University Medical Center is one of only five hospitals in the U.S. selected […]

Aug 15, 2022 | Cath Lab Digest

The global consensus document† is a novel approach to determining next steps on how to use intravascular imaging for peripheral revascularization. We have already seen the success of IVUS in the coronary space during percutaneous coronary intervention. We have a fair amount of observational cohort data examining the benefits of IVUS for lower extremity arterial […]

Major manifestations of age-associated CV dysfunction that increase disease risk are vascular dysfunction, primarily vascular endothelial dysfunction and arterial stiffening, and elevated systolic blood pressure.

Aug 1, 2022 | Cardiac Rhythm News

People who develop an arrhythmia after surgery have an increased risk of subsequently being admitted to hospital with heart failure, according to a study of over three million patients published in the European Heart Journal.

Jul 25, 2022 | TCTMD

Individual patient-level registry data show that place of residence mattered more in 2020 than comorbidities and COVID severity.

Vascular Disease Management speaks with vascular surgeon Halim Yammine, MD, from Sanger Heart and Vascular Institute in Charlotte, North Carolina, about treating calcified PAD with the Shockwave M5+intravascular lithotripsy (IVL) catheter. Dr. Yammine’s case report follows the interview.

Jul 11, 2022 | EP Lab Digest

This case report describes the follow-up and long-term care of a 68-year-old woman who participated in the original series at Columbia-Presbyterian Medical Center (1960-1965) and underwent a novel surgical procedure for complete correction of Tetralogy of Fallot.

STEMIN and YAP5SA mmRNA improved cardiac function and myocardial fibrosis in left ventricles of infarcted adult mice. The combinatorial use of mmRNA encoding STEMIN and YAP5SA has the potential to become a powerful clinical strategy to treat human heart disease.

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